From Atom to Animal: Decoding the Multi-Scale Mechanisms of Influenza Entry
■ Date: Thursday, May 14th
■ Time: 10:00 CEST / 13:30 IST / 16:00 SGT / 17:00 JST
| ■ Venue: | ONLINE |
| *Webinar platform ON24 will be used, There is no need to download any app. |
■ Fee: Free of Charge
| ■ Registration: | After completing the application, the URL will be sent to you. |
■ Webinar Introduction:
This webinar explores a multi-scale approach to Influenza A Virus (IAV) entry, following our research philosophy that spans "from atom to animal." We examine how IAV subverts host machineries—identified through unbiased RNAi and chemoproteomic screens—to regulate the sequential stages of uptake, uncoating, and genome delivery. Using automated spinning-disk confocal (CQ1) and super-resolution (CSU-W1 SoRa) microscopy, we quantify these virus cell entry dynamics in vitro before validating our finding with in vivo mouse models.
By pairing high-speed fluorescence with advanced image analysis, we quantify individual virion diffusion and real-time membrane remodeling during viral endocytosis. We will also discuss the future aim of achieving unprecedented spatiotemporal resolution by further developing the Virus-View Dual Confocal and Atomic Force Microscopy (ViViD-AFM) platform to integrate the Yokogawa CSU-W1 SoRa. Decoding these intricate virus-host interfaces is pivotal for the rational design of next-generation broad-spectrum antivirals.
Key topics include:
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Inquiry
if you have any question about this webinar,or if you would like to change your registration details, please feel free to contact lsc_news@cs.jp.yokogawa.com.
Prof. Dr. Yohei Yamauchi
Department of Chemistry and Applied Biosciences, ETH Zurich
Yohei Yamauchi is a Professor of Molecular Medicine at the Institute of Pharmaceutical Sciences at ETH Zurich. His research focuses on the molecular and cellular mechanisms of viral entry and uncoating, with applications in antiviral and vaccine development. His laboratory integrates high-resolution imaging and biophysical techniques, notably ViViD-AFM—a hybrid confocal AFM technology that achieves nanometer resolution of virus-cell interactions in live cells. Prof. Yamauchi is a Fellow of the Royal Society of Biology (FRSB) and holds visiting professorships at the University of Bristol and Nagoya University.
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