yokogawalogo

Brain MPS overcoming challenges of complex

in vitro models with modern tools

■ Date: Tuesday, November 11th

■ Time: 11am ET/8am PT for US
　　　　5pm CET for Europe

■ Venue: ONLINE
  *Webinar platform ON24 will be used, There is no need to download any app.

■ Fee: Free of Charge

■ Registration: After completing the application, the URL will be sent to you.
   

■ Webinar Introduction:
Advances in stem cell technology and bioengineering have enabled the development of brain microphysiological systems (bMPS)—human iPSC-derived organoids, assembloids, and organ-on-chip platforms that recapitulate essential features of neurodevelopment and function. These models offer insight into neurotoxicity, disease mechanisms, and gene–environment interactions, while overcoming key limitations of animal models. In this webinar, we will explore how modern tools—including high content and live imaging, HD-MEA recordings, and genetically engineered reporter lines—help address the challenges of complexity, reproducibility, and functional validation in bMPS. Case studies will illustrate applications from modeling synaptic disruption by metal mixtures, neuroinflammatory responses in autism-associated genotypes, to domoic acid’s impact on memory-linked neural dynamics. We will also discuss emerging efforts in standardization, immune competence, and cognitive function modeling—bringing brain MPS closer for regulatory integration and next-generation in vitro neurotoxicity testing.

Key topics include:

  • Utilization of Modern Tools: High content and live imaging, HD-MEA recordings, genetically engineered reporter lines.
  • Case Studies: Modeling synaptic disruption by metal mixtures, neuroinflammatory responses in autism-associated genotypes, domoic acid’s impact on memory-linked neural dynamics.
  • Efforts in Standardization: Regulatory integration and next-generation in vitro neurotoxicity testing. 

 

Recommended system requirements
Windows 10+ (Latest Microsoft Edge, Firefox, or Chrome)
Apple Mac OS 10.10+ (*Latest Safari, Firefox, or Chrome)
Android 9+ (Latest Chrome Browser)
Apple iOS 12+ (*Latest Safari Browser)
The webinar will take place on On24. Please refer to the recommended system requirements for viewing here.

Inquiry
if you have any question about this webinar,or if you would like to change your registration details, please feel free to contact webinar_support@ml.jp.yokogawa.com.

Speaker

Lena Smirnova, PhD

Bloomberg School of Public Health, Johns Hopkins 

Registration